Subhashree priyadarsini

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Dr. Subhashree priyadarsini is currently serving as Guest Faculty at Department of Botany and Biotechnology, Ravenshaw University. She completed her PhD on June 2020, from the Department of Life Science, National Institute of Technology, Rourkela. She has five years of research experience in the field of pathogenic oral microbial effect on the physiology of model organism, Drosophila. Her doctoral thesis is on the effects of teeth blackening bacteria Enterobacter ludwigii, which was isolated from human oral cavity, on the body’s physiology and development, which was investigated by using Drosophila melanogaster a model organism. Her research interests concentrate on developmental neuroscience, examining bio toxicity of various nanoparticles, so that it can be used as a Nano medicine to treat a particular disease. She has 7 research papers in international journals, 2 conference proceedings as well as 4 book-chapters to her credit.

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Dr. Subhashree Priyadarsini studied the effect of one oral pathogenic microbe, Enterobacter ludwigii and its suppressor graphene nanosheets on fly physiology. So, her research work entirely describes the impact of that cariogenic bacteria Enterobacter ludwigii in modulating body morphology and physiology of the Drosophila melanogaster. For that, bacteria were isolated from infected human oral cavity, whose effect on body has never been looked at. Next, the alteration in the genotype and behavioral phenotype of Drosophila because of the extra supplementation of a neurotransmitter, histidine has been checked.

She has reported that histidine acts as a teratogen in Drosophila melanogaster in a dose-dependent manner.  Also the effect of bacterial infection on fat accumulation and glucose metabolism of Drosophila has been studied and it was found out that E. ludwigii induces type II diabetes-like symptoms in flies by affecting its metabolism.

As this is a tooth blackening bacteria, so to combat the disease; various nanoparticles having antimicrobial property was checked and among them graphene nanomaterial was found out to have the best antimicrobial property against E. ludwigii. Thus its impact in inhibiting the pathogenicity of bacteria in the fly body has been studied. The nontoxic effect of graphene nanosheets has also been investigated in fly physiology. Graphene is known to be a nanoparticle, which can inhibit the growth of the bacteria at a lower dose. Along with this, characterisation of bacteria infected baby teeth, adult teeth and adult stained teeth has been studied.

Excluding that, she has also done 1-year dissertation work on the topic entitled “myc-miRNA-transcript regulatory crosstalk in STS oncogenesis”, from NIT, Rourkela. As well as did her Summer internship on the project entitled “characterisation of arsenic resistant bacteria on marine environment” at CSIR-IMMT, BHUBANESWAR.

Internationally indexed journals: -

  1. Priyadarsini, S., M. Sahoo, S. Sahu, R. Jayabalan and M. Mishra (2019). “An infection of Enterobacter ludwigii affects development and causes age-dependent neurodegeneration in Drosophila melanogaster.” Invertebrate Neuroscience 19(4): 13. IF-0.8 
  2. Priyadarsini, S., et al. (2019). ” Oral administration of graphene oxide nano-sheets induces oxidative stress, genotoxicity, and behavioral teratogenicity in Drosophila melanogaster.” Environmental Science and Pollution Research: Volume 26, Issue 19, pp 19560–19574. IF-2.914 
  3. Priyadarsini, S., S. Mukherjee, S. Samikshya, A. Bhanja, S. Paikara, N. Nayak and M. Mishra (2020). “Dietary infection of Enterobacter ludwigii causes fat accumulation and resulted in the diabetes-like condition in Drosophila melanogaster.” Microbial Pathogenesis: volume 149, pp 104276. IF-2.581
  4. Priyadarsini, S., Mukherjee, S., & Mishra, M. (2017). Nanoparticles used in dentistry; a review. Journal of Oral Biology and Craniofacial Research. Highly cited article for 2018 and 2019. IF- 1.33 
  5. Priyadarsini, S., et al. (2018). “Graphene and graphene oxide as nanomaterials for medicine and biology application.” Journal of Nanostructure in Chemistry: 1-15. IF-4.077 
  6. Konar, M., N. Nayak, S. Priyadarsini, M. Mishra and H. Sahoo (2019). “Antimicrobial activity of nanoparticle-based dental fillers on novel chromogenic bacteria Enterobacter ludwigii.” Materials Research Express 6(8): 085407. IF-1.410 
  7. 7. Sabat, D., Priyadarsini, S., & Mishra, M. (2016). Understanding the Structural and Developmental Aspect of Simple Eye of Drosophila: The Ocelli. J Cell Signal, 1(109), 2. IF- 3.968

Book chapter: -

  1. Satpathy A., Ranjan R., Priyadarsini S., Gupta S., Mathur P., Mishra M. (2019) Diagnostic Imaging Techniques in Oral Diseases. In: Shukla A. (eds) Medical Imaging Methods. Springer, Singapore 
  2. Priyadarsini, S., et al. (2020). Application of Nanoparticles in Dentistry: Current Trends. Nanoparticles in Medicine, Springer: 55-98. 
  3. Priyadarsini S, Sumit Mukherjee and Monalisa Mishra (2020) Methodology to detect the abnormality of Drosophila gut by various staining techniques. Fundamental approached to screen abnormalities in flie. Springer protocols. USA. pp 51-64 
  4. Priyadarsini S, Sumit Mukherjee, Monalisa Mishra (2020) Formulation of Drosophila food for various feeding studies. Fundamental approached to screen abnormalities in flie. Springer protocols., USA pp 1-13 

Teaching :

  • Post Graduate:
  1. Cell biology and biomolecules
  2. Carbohydrate metabolism
  3. Immunology
  4. Bio-Instrumentation
  5. Genetic engineering & gene therapy
  6. Animal Biotechnology
  7. Bioprocess technology (Downstream processing)

Prior to that she worked as TA for 3 years for different semester during doctorate time and was handling practical classes of students for developmental biology and animal physiology of MSc. students in National institute of technology, Rourkela.