Neurobiology

Manorama Patri

Room No. - 302
New Academic Block

Phone no.

drpatri[at] ravenshawuniversity[dot] ac[dot]in

She held the post of Assistant Professor in the  Department of Zoology, Ravenshaw University. She has 20 years of teaching and more than 15 years of research experience in the field of Cognitive Neuroscience. She has completed her Ph.D. in 2000 from Sambalpur University. She worked as a Postdoctoral Fellow in Human Stress Signal Research Center (HSS), Advanced Industrial Science and Technology (AIST), Kansai Center, Japan on Stress and Neuro-Developmental Disorders.  She worked in the Central University of Hyderabad on Stem cell therapy in the Department of Animal Science. Later she moved to the Neurobiology Laboratory at Jawaharlal Nehru University, New Delhi, as a Women Scientist (DST, WOS “A”) Fellow and worked on “Cellular and Molecular Mechanism of Learning and Memory”. She is a life member of Indian Academy of Neuroscience (IAN), Society for Neurochemistry, India (SNCI) and Odisha Bigyan Academy (OBA).

Her current research interest mainly focuses on gut microbiota and their interaction with brain, resulting changes in central nervous system function and cognitive behavior.

Selected Publications

  1. Mohanta L, Das B.C. and Patri M (2020) Microbial communities modulating brain functioning & behaviours in zebrafish: A mechanistic approach; Microbial Pathogenesis, 145:104251.
  2. Rath SN and Patri M (2019) Understanding ligands driven mechanism of wild and mutant AhR in presence of phyto-chemicals combating PD: an in silico and in vivo study, Journal of biomolecular Structure & Dynamics, 5:1-20.
  3. Mohanty R, Das SK and Patri M (2017); Modulation of benzo[a]pyrene induced anxiolytic like behavior by retinoic acid in Zebrafish: involvement of oxidative stress and antioxidant defence system; Journal of Neurotoxicity Research; 31(4), 493-504, 2017.
  4. Das SK and Patri M (2016); NPY expression confers B[a]P induced anxiolytic like behavioral response during early adolescence period of male Wistar rats; Neuropeptides; 61:23-30.
  5. Patri M, Singh A and Mallick BN (2013); Protective Role of Noradrenalin in Benzo[a]pyrene-induced Learning Impairment in Developing Rat, Journal of Neuroscience Research, 91:1450–1462.
  • Group
  • Research
  • Publications
  • Teachings

Group Alumni

Mrs. Aparajita Panda

Thesis Title : Impact of physicochemical variations in some water of Chilika Lagoon on biochemical and physiological parameters of Liza tade

Mr. Surya Narayan Rath

Thesis Title : screening of plant based natural compounds for    management of parkinson disease through computational   approach.

Mrs. Sushma Martha

Thesis Title : Comparative analysis of drug metabolites on the complex brain disorder schizophrenia.

Ms. Sai Aparna

Thesis Title : Nrf2 mediated neuroprotective efficacy of Glycine max seed extract against Benzo[a]pyrene induced neurotoxicity in zebrafish

Mrs. Ipsita Mohanty

Thesis Title : Pentylenetetrazole-indiced Epileptic Seizures in rats and its possible amelioration through Marselia quadrifolia leaf extract: A mechanistic Explorati    

Dr. Saroj Das

Thesis Title : Evaluation of genotoxic potential of benzo[a]pyrene on neurobehavioral responses and dopaminergic system in Zebrafish (Danio rerio) and its consequences on F1 offspring

Dr. Bhupesh Patel

Thesis Title : Effects of Benzo[a]pyrene on antioxidant defence system of hippocampus during early adolescence period of male Wistar rats.

Dr. Ratnalipi Mohanty

Thesis Title : Modulation of oxidative stress indices and Cytochrome P 450 enzymes in zebrafish (danio rerio) by benzo[a]pyrene and its role in neurobehavior.

Dr. Poonpun Das

Thesis Title : Polycyclic Aromatic Hydrocarbon in Maternal blood, Placenta, Cord blood: A cross sectional study.

Dr. Lipsa Das

Thesis Title : Effect of in utero exposure to Benzo[a]pyrene on the level of catecholamine, activity of monoamine oxidase and cytomormhometry of rat brain.

Modulation of benzo[a]pyrene induced anxiolytic-like behavior by exogenous and endogenous antioxidants:

Both the exogenous and endogenous antioxidants are found to be effective in prevention of free radical formation. The findings of our laboratory showed Withania somnifera leaf extract can be used for its neuroprotective effect in experimental models of neurological disorders. Retinoic Acid (RA) as endogenous antioxidant can mediate neuroprotection and restores normal neurobehavioral response of zebrafish by counteracting the B[a]P-induced oxidative stress possibly through augmented glutathione biosynthesis.

16

Role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms:

Aryl Hydrocarbon Receptor (AhR) is a key player to regulate the expression of a group of enzymes known as cytochrome P450s (CYPs). B[a]P induces oxidative stress and causes degeneration of dopaminergic neurons that may lead to Parkinson’s disease (PD). Our research findings showed Withanolide A may act as a potent phytochemical to trigger the AhR mediated gene regulation activity of CYPs.

17

Protective Role of Noradrenaline in Benzo[a]Pyrene-induced Learning and Memory Impairment :

During cellular metabolism reactive oxygen species (ROS) are generated results in alteration of antioxidant enzymes (GST, GPx, GR and total glutathione) and leading towards behavioural changes with altered neuronal morphology in the hippocampus of adult wistar rat brain. Early exposure to B[a]P correlates with impaired learning and memory in adults, and reduction in dendrite population in CA1 regions of hippocampus during development. Noradrenaline (NA) exerted a protective effect by modulating those factors.

Mechanism B[a]P metabolism by cytochrome P450 enzymes activation.

18

Projects

  1. To study the possible mechanism and role of NMDA receptor in B[a]P-induced behavioral changes and neuronal apoptosis- 3 Years (2015-18) – BRNS, Mumbai.
  2. Learning and memory deficits with molecular dysfunction following environmental exposure to benzo(a)pyrene 3 Years and 6 Months (2010-13) – WOS ‘A’ DST, Govt of India.
  3. Study the effects of hypoxia on B[a]P induced behavioral changes and expression of neurotrophic factors during Zebrafish (Danio rerio) development – 3 Years (2017-21) DRDO, New Delhi.
  4. Behavioral changes and oxidative DNA damage via DNA methylation on early exposure to benzo(a)pyrene during development of Zebrafish embryos 3 Years (2017-20) (Dept of Science & Technology), Govt. of Odisha.
  5. Evaluation of genotoxic potential of B[a]P on neurobehavioral responses and dopaminergic systems in adult zebrafish and its consequences on F1 offspring 2 Years (2016-18) (DST, SERB), Govt. of India.
  1. Martha S.R. and Patri M (2021) Energy-based virtual screening of drugs documented for schizophrenia against DRD2 and HTR2A; J. Computational Vision and Robotics, IJCVR 0X0Y0X PATRI_296086 (Accepted)
  2. Nanda A and Patri M (2021) Effect of Amlodipine in Proliferative Retinopathy: Biochemical Estimation and Zebrafish (Danio rerio) Modelling; RJPT, Vol: 15, Issue: 3.
  3. Rath, SN, Jena L and Patri M (2021) In silico discovery and evaluation of phytochemicals binding mechanism against human Catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson’s disease, Genomics and Informatics, 2021; 19(1): e7doi.org/10.5808/gi.20061.
  4. Rath, SN, Ray M and Patri M (2020) Computational discovery and assessment of non-synonymous single Nucleotide polymorphisms from target gene pool associated with PD, Gene Reports; 21:100947.
  5. Sai Aparna and Patri M (2020) B[a]P exposure and overcrowding stress impacts anxiety-like behavior and impairs learning and memory in adult zebrafish, Danio rerio, DOI: 10.1002/TOX.23041.
  6. Mohanta L, Das B.C. and Patri M (2020) Microbial communities modulating brain functioning & behaviours in zebrafish: A mechanistic approach; J. Microbial Pathogenesis, 145:104251.
  7. Mahanta C.S., Patri M and Satapathy R.K. (2020) Star-shaped phenylene BODIPY: Synthesis, properties, and biocompatibility assessment using zebrafish ChemestrySelect:doi.org/10.1002/slct.202001954
  8. Martha S.R. and Patri M (2020) Network Driven Discovery of Dopamine, Serotonin and Glutamate Receptors as Key Players in Schizophrenia, JSIR; Vol. 79, May 2020, pp.1-7.
  9. Rath S.N. and Patri M (2020) Understanding miRNA based gene regulation in Parkinson’s disease: an in silico approach; Int. J. Bio automation; 2020, 24(1), 15-28.
  10. Panda A and Patri M. (2020) Histopathological changes and presence of rodlet cells in different organs of common finfish Liza tade in brackish water of the Chilika Lagoon; International Journal of Fisheries and Aquatic Studies 2020; 8(5): 186-196.
  1. Panda A and Patri M. (2020) Food And Feeding Behaviour of Tade gray Mullet, Liza tade in Chilka Lagoon, Odisha, India; J. Appl. Zool. Res. (2): 184-192.
  2. Das L, Patel B and Patri M (2019) Adolescence B[a]P treatment induces learning and memory impairment and anxiolytic like behavioral response altering neuronal morphology of hippocampus in adult male Wistar rats, Toxicology Reports 6, 1104–1113.
  3. Das, S. K., Sai Aparna and Patri M (2019) Chronic waterborne exposure to B[a]P-induces locomotor dysfunction & development of neurodegenerative phenotypes in zebrafish, JNL; https://doi.org/10.1016/j.neulet.2019.134646.
  4. Singh A and Patri M (2019) Protective effects of Noradrenaline on B[a]P induced oxidative stress responses in brain tumor cell lines; In Vitro CDB-Animal, 55:665–675.
  5. Das L and Patri M (2019) Prenatal exposure to B[a]P causes learning and memory impairment & loss of neurons in hippocampus during development of Wistar rats; IJMB: Open A, 4(4), 124-130.
  6. Das L and Patri M (2019) Impact of Environmental Pollution on Respirator System of Human & Animals in Angul and Talcher Industrial Areas, Odisha, India: A Case Study; IJZAB, 2(6), 1-15.
  7. Rath SN and Patri M (2019) Understanding ligands driven mechanism of wild and mutant AhR in presence of phyto-chemicals combating PD: an in silico and in vivo study, J BSD, 5:1-20.
  1. Das S.P. & Patri, M (2019) Therapeutic Uses of Curd: A Review; IOSR J, Vol. 13 (1), 1-4.
  2. Das P and Patri M (2018), Exposure of Pregnant Women to Air Pollution in Odisha, India: A Case Study; JSM Health Education & Primary Health 2(3);1034-1038.
  3. Martha SR, Mallik D and Patri M (2017) Genome wide screening and analysis of Homo sapiens genes and proteins associated with schizophrenia, RJRS; 6(7), 63-70.
  4. Mohanty R, Das SK and Patri M (2017); Modulation of benzo[a]pyrene induced anxiolytic-like behavior by retinoic acid in Zebrafish: involvement of oxidative stress and antioxidant defence system; Neurotoxicity Research; 31(4), 493-504, 2017.
  1. Das SK and Patri M (2016); NPY expression confers B[a]P induced anxiolytic like behavioral response during early adolescence period of male Wistar rats; Neuropeptides; 61:23-30.
  2. Patel B, Das SK and Patri M (2016); Neonatal B[a]P exposure induces oxidative stress and DNA damage causing neurobehavioral changes during early adolescence period of rat, Journal of Developmental Neuroscience; 38(2):150-62.
  3. Mohanty R, Das SK and Patri M (2016); ‘Withania somnifera leaf extract ameliorate B[a]P induced behavioral and neuro-morphological alterations by improving brain antioxidant status in Zebrafish (Danio rerio)’; Zebrafish; 13(3):188-96.
  4. Das SK, Patel B and Patri M (2016) Neurotoxic effect of B[a]P and its possible association with 6-hydroxydopamine induced neurobehavioral changes during early adolescence period in rats’; Journal of Toxicology; doi: 10.1155/2016/8606410.
  5. Patel B, Das SK and Patri M (2016); ‘Neonatal exposure to B[a]P induces oxidative stress causing altered hippocampal cytomorphometry and behavior during early adolescence period of male Wistar rats’; IJDN; 50:7-15.
  6. Patri M, Singh A and Mallick BN (2013); Protective Role of Noradrenalin in Benzo[a]pyrene-Induced Learning Impairment in Developing Rat, JNR, 91:1450–1462.
  1. Patri M, Padmini A. and Babu P. P (2010); PAHs exposure induced oxidative stress and neurological disorders: A brief perspective; Annals of Neurosciences 16(1) January; 22-30.
  1. Basics of Neuroscience
  2. Animal diversity
  3. Developmental Biology
  4. Genetics
  5. Physiology
  6. Neuro- & Behavioral Biology
  7. Cell Biology