Stress Physiology and Neurotoxicology

Dr. Srikanta Jena

Room No. - 302
New Academic Block

Phone no.

Email

He holds the position of Assistant Professor in the Department of Zoology. He has more than10 years of teaching and research experienec. He has completed his Ph.D. in the year 2012 from Department of Biotechnology, Utkal University. His research area is on stress physiology, endocrine regulations and neurotoxicology. He has 18 publications in peer review journals, 9 as proceedings/preprints and 3 book chapters in to his credit.

Currently his group is interested to explore on following aspects:

  • Characterization of drug resistant HIV-1 mutants by genomic and proteomic approaches.
  • Ecological distribution, conservation strategies and phylogenetic relationship among different species of non-marine chelonians of Odisha
  • Fluoride toxicity on health of aquatic organisms and its management.
  • Role of curcumin on collagen expression and its involvement in β-amyloid formation in hypothyroid rat brain.

Selected Publications

  1. Vinod C, Jena S. Nano-Neurotheranostics: Impact of Nanoparticles on neural dysfunctions and strategies to reduce toxicity for improved efficacy. Frontiers in Pharmacology- Predictive Toxicology (2021) doi: 10.3389/fphar.2021.612692. [Impact Factor: 4.225] ISSN 1663-9812
  2. Barik SK, Mohanty KK, Ashok, Mohanty AK, Rawat P, Gopal G, Bisht D, Patil SA, Singh R, Sharma D, Tripathy SP, Tandon R, Singh TP and Jena S. Identification and differential expression of serotransferrin and apolipoprotein A-I in the plasma of HIV-1 patients treated with first-line antiretroviral therapy. BMC Infectious Disease. 20:898 (2020). https://doi.org/10.1186/s12879-020-05610-6. [Impact Factor]: 2.864] ISSN: 471-2334
  3. Mishra P, Paital BR, Jena S, Swain SS, Kumar S, Yadav MK, Chainy GBN, Samanta L. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart. Scientific Reports (2019) 9:7408, https://doi.org/10.1038/s41598-019-43320-5. [Impact Factor:4.576] ISSN: 2045-2322
  4. Das SK, Prusty A, Samantaray D, Hasan M, Jena S, Patra JK, Samanta L, Thatoi H. Effect of Xylocarpus granatum Bark Extract on Amelioration of Hyperglycaemia and Oxidative Stress Associated Complications in STZ-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine (2019) 3:1-13, https://doi.org/10.1155/2019/8493190. [Impact Factor: 1.813] ISSN:1741-427X (print), 1741-4288 (web)
  5. Jena S. Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain. Neurological Sciences (2015) 36(6):953-9. DOI 10.1007/s10072-015-2199-9 [Impact Factor: 2.415] ISSN: 1590-1874 (print), 1590-3478 (web).
  • Group
  • Research
  • Publications
  • Teachings

Chitrasen Sethy

Thesis Title : Studies on ecology, distribution, conservation strategies and phylogenetic relationship among different species of non-marine chelonians of Odisha

Sushanta Kumar Barik

Thesis Title : Characterization of drug resistant HIV-1 mutants of Agra region, India by genomic and proteomic approaches.

Jayashree Prusty

Thesis Title : Sodium fluoride toxicity on oxidative stress and antioxidant defence system in different tissues of Goldfish: effect of Ascorbic acid.

Sulata Kumari Sahu

Thesis Title : Effect of curcumin on TGF- β signalling mediated collagen expression and its role in regulation of β-amyloid formation in hypothyroid rat brain

Samar Gourav Pati

Thesis Title : Impact of seasonal variation on redox regulation and nutritional values in tissues of Scylla serrate.

M.Phil students

  1. Arpita Prusty (2015)          
  2. Jayashree Prusty (2016)  
  3. Smita Patri (2017)
  4. Amrita Lenka (2018)

Thyroid Hormone alteration causes stress and affects brain functions.

Curcumin supplementation reduces oxidative stress and enhances brain functions under altered thyroid states.

Food deprivation and temperature fluctuation affects fish Physiology and metabolism

  1. Vinod CJena S. Nano-Neurotheranostics: Impact of Nanoparticles on neural dysfunctions and strategies to reduce toxicity for improved efficacy. Frontiers in Pharmacology- Predictive Toxicology (2021) doi: 10.3389/fphar.2021.612692. [Impact Factor: 5.81]  ISSN 1663-9812
  2. Barik SK, Varshney D, Mohanty KK, Bisht D, Patil SA, Singh R, Sharma D, Tripathy SP, Tandon R, Singh TP, Jena S. Comparative evaluation of plasma protein purification and 2-D gel electrophoresis protocols for analysis of HIV-1 infected human plasma proteins. Science, Technology and Development Journal (2021) Vol X (IV): 1-9. DOI:21.18001.STD.2021.V10I4.21.350800
  3. Barik SK, Bansal AK, Mohanty PS, Tripathy SP, Hanna LE, Karunaianantham R, Pattabiraman S, Singh TP, Tandon R, Tomar S, Jena S, Patil SA, Mohanty KK. Detection of drug resistance mutants in reverse transcriptase gene of HIV-1-infected North Indian population failing first line antiviral therapy “A folow-up cohort study”. AIDS Ressearch and Human Retroviruses (2021) doi: 10.1089/AID.2020.0132 [Impact Factor: 2.205]  ISSN: 0889-2229 (print); 1931-8405 (web)
  4. Barik SK, Singh D, Mohanty PS, Tripathy SP, Jena S, Dwivedi V.D, Mohanty, K.K. Molecular modelling of HIV-1 drug resistant mutants with reference to wild type. International Journal of Pharmaceutical Sciences and Research (2021); 12(2): 1263-71. doi:10.13040/IJPSR.0975-8232. 12(2).1263-71. E-ISSN: 0975-8232; P-ISSN: 2320-5148
  5. Barik SK , Mohanty KK, Mohanty AK, Rawat P, Gopal G, Bisht D, Patil SA, Singh R, Sharma D, Tripathy SP, Tandon R, Singh TP and Jena S. Identification and differential expression of serotransferrin and apolipoprotein A-I in the plasma of HIV-1 patients treated with first-line antiretroviral therapy. BMC Infectious Disease. 20:898 (2020). https://doi.org/10.1186/s12879-020-05610-6. [Impact Factor]: 3.09] ISSN: 471-2334
  6. Mishra P, Paital BR, Jena S, Swain SS, Kumar S, Yadav MK, Chainy GBN, Samanta L. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart. Scientific Reports (2019) 9:7408, https://doi.org/10.1038/s41598-019-43320-5. [Impact Factor: 4.379] ISSN: 2045-2322
  7. Das SK, Prusty A, Samantaray D, Hasan M, Jena S, Patra JK , Samanta L, Thatoi H. Effect of Xylocarpus granatum Bark Extract on Amelioration of Hyperglycaemia and Oxidative Stress Associated Complications in STZ-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine (2019) 3:1-13, https://doi.org/10.1155/2019/8493190. [Impact Factor: 2.629] ISSN:1741-427X (print), 1741-4288 (web)
  8. Barik SK, Mohanty KK, Bisht D, Joshi B, Jena S, Tripathy SP. An Overview of Enzyme Immunoassay: The Test Generation Assay in HIV/ AIDS Testing. Journal of AIDS and Clinical Research (2018), 9:762. DOI: 10.4172/2155-6113.1000762. ISSN: 2155-6113
  9. Barik SK, Tomar S, Tandon R, Mohanty KK, Joshi B, Bisht D, Jena S, Tripathy SP. Practical Challenges in Implementing a Simplified Leaflet for HIV Patients in Resource Poor Settings: The Practice towards Public Health. Journal of General Practice (2018) 6:347. DOI: 10.4172/2329-9126.1000347. ISSN: 2329-9126.
  10. Jena S. Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain. Neurological Sciences (2015) 36(6):953-9. DOI 10.1007/s10072-015-2199-9 [Impact Factor: 3.307] ISSN: 1590-1874 (print), 1590-3478 (web).
  11. Jena S, Bhanja S. Hypothyroidism alters antioxidant defence system in rat brainstem during postnatal development and adulthood. Neurological Sciences (2014) 35(8):1269-74. DOI: 10.1007/s10072-014-1697-5 [Impact Factor: 3.307]. ISSN: 1590-1874 (print), 1590-3478 (web)
  12. Jena S, Dandapat J, Chainy GBN. Curcumin differentially regulates the expression of superoxide dismutase in cerebral cortex and cerebellum of L-thyroxine (T4)-induced hyperthyroid rat brain. Neurological Sciences (2013) 34(4):505-510 DOI 10.1007/s10072-012-108-z [Impact Factor:  3.307]. ISSN: 1590-1874 (print) 1590-3478 (web).
  13. Bhanja S, Jena S. Modulation of antioxidant enzyme expression by PTU-induced hypothyroidism in cerebral cortex of postnatal rat brain. Neurochemical Research (2013) 38(1):42-9. DOI: 10.1007/s11064-012-0885-z [Impact Factor: 3.996). ISSN: 0364-3190 (Print), 0364-3190 (web).
  14. Srikanta Jena*, Chinmay Anand, Gagan Bihari Nityananda Chainy, Jagneswar Dandapat. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin. Neurological Sciences (2012) 33(4):869-873 DOI 10.1007/s10072-011-0853-4 [Impact Factor: 3.307] ISSN: 1590-1874 (print) 1590-3478 (web).
  15. Jena S, Chainy GBN. Jagneswar Dandapat. Hypothyroidism modulates renal antioxidant gene expression during postnatal development and maturation in rat.  General and Comparative Endocrinology (2012) 1;178(1):8-18. DOI: 10.1016/j.ygcen [Impact Factor: 2.822]. ISSN: 0016-6480.
  16. Jena S. Gagan Bihari Nityananda Chainy, Jagneshwar Dandapat. Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin. Molecular Biology Reports (2012) 39(2):1193-1203, DOI 10.1007/s11033-011-0849-4 [Impact Factor: 2.316] ISSN‎: ‎0301-4851 (print); 1573-4978 (web).
  17. Jena S and Chainy GBN. Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L-thyroxine induced oxidative stress in rat renal cortex. Molecular Biology Reports (2011) 38(2):1047-1054, DOI10.1007/s11033-010-0201-4 [Impact Factor: 2.316] ISSN‎: ‎0301-4851 (print); 1573-4978 (web).
  18. Jena S, Chainy GBN. Effect of Methylene Blue on oxidative stress and antioxidant defence parameters of rat hepatic and renal tissues. Indian Journal of Physiology and Pharmacology (2008) 52 (3): 293-296. ISSN: 0019-5499

Book Chapter Publications :

  1. Prusty J, Jena S. Bioactive Compounds and Herbal Therapy for Alzheimer’s Disease. Bioresource Utilization and Management: Applications in Therapeutics, Biofuels, Agriculture, and Environmental Science. Publisher: Apple Academic Press (CRC Press, Taylor & Francis Group). 2021: Hard ISBN: 9781771889339, e-Book ISBN: 9781003057826
  2. Sahoo DK, Jena S, Chainy GBN. Thyroid Dysfunction and Testicular Redox Status: An Intriguing Association. Oxidants, Antioxidants and the Impact of the Oxidative Status in Male Reproduction. pp 149-170(2018). Publisher: Elsevier. ISBN: 978-0-12-812501-4.
  3. Jena S, Bunker SK, Dandapat J, Chainy GBN. Age-related changes in antioxidant enzymes of rat kidney and oxidative stress parameters with special reference to methylation of the catalase promoter. Topic in Medical Gerontology. pp 41-160 (2017). Publisher: Springer Singapore. ISBN 9789811021558; Hardcover ISBN 9789811021541.
  1. Molecular Biology
  2. Cell Biology
  3. Biotechnology
  4. Biochemistry