Enzymology and Cancer Biology

Dr. Dhananjay Soren

Room No. - 304
Academic Block

+91-9337206151

dsoren@ravenshawuniversity.ac.in

Dr. Soren completed his Ph. D in 2010, since then he is actively involved in addressing on secretion dynamics of enzyme from fungi at Applied Biochemistry/ Drug Development/Diagnostics and Biotechnology Division, CSIR- Indian Institute of Chemical Biology, Kolkata, India. He joined the Department of Zoology, Ravenshaw University as as Assistant Professor in the year 2010.

His research group is currently working on purification and characterization of different industrial enzymes from microbial sources. The antibiotics resistance in microbe and their evolution is another area of his challenges. Currently his laboratory is working on microbial association and their pathogenesis leading to neoplasia in humans.

Selected Publications

  1. Pattanayak B.S., Dehury, B., Priyadarshinee, M., Jha, S., Beuria, T.K., Soren, D., Mallick, C. (2021) Kanamycin-mediated conformational dynamics of Escherichia coli outer membrane protein TolC. Frontiers in Molecular Biosciences, 8: Article 636286, [doi:10.3389/fmolb.2021.636286].
  2. Nayak, , Patnaik, P., Mohapatra, M., Soren, D., Patra, P., Besra, K., Giri, S.K. (2020) Bacterial Vaginosis and its association with Human Papilloma Virus and increased risk of Cervical Intraepithelial Lesions: An experience from Eastern India. Oncology Journal of India, 4(2), 67-72.
  3. Dutta T, Banerjee S, Soren D, Lahiri S, Sengupta S, Rasquinha JA, Ghosh AK. (2012) Regulation of enzymatic activity by deamidation and their subsequent repair by protein L-isoaspartyl methyl transferase. Appl Biochem Biotechnol. Vol. 168(8):2358- 75.
  4. Lahiri S, Basu A, Sengupta S, Banerjee S, Dutta T, Soren D, Chattopadhyay K, Ghosh (2012) Purification and characterization of a trehalase-invertase enzyme with dual activity from Candida utilis. Arch Biochem Biophys. Vol. 15;522 (2):90-9.
  5. Soren D, Jana M, Sengupta S, Ghosh AK. (2010) Purification and characterization of a low molecular weight endo-xylanase from mushroom Termitomyces clypeatus. Appl Biochem Biotechnol. 162(2):373-89.
  • Group
  • Research
  • Publications
  • Teachings

Jibanbandhu Das

Thesis Title : Effect of mining activities and industrialization on biomarkers in the tissues of fresh water fishes of Brahmani river.

Soumya Prasad Panda

Thesis Title : Molecular characterization of antiviral Mx gene in Catla catla.

Jyoti Ranjan Mohanty

Thesis Title : Biological markers of oxidative stress: Application to urinary tract infection and practice in women of different age groups of Odisha.

Amrita Swain

Thesis Title : Role of GlcNAc in bacterial signaling.

Nalinibala Behera

Thesis Title : Effect of dietary supplementation on growth of Indian Major Carp Labeo rohita.

Group Alumni

Dr. Manas Ranjan Dash

Thesis Title : Testing of genotoxic potentials of some new generation antibiotics using in vivo vertebrate system.

Dr. Biraja Sankar Pattanayak

Thesis Title : Biochemical and biophysical characterization of drug efflux protein in E. coli.

Dr. Pallavi Patnaik

Thesis Title : Biology of bacterial vaginosis (BV) by sialidase detection and assessment of its correlation if any with cervical cancer.

The pathogenic microbial association with predominant Lactobacilli of vaginal milieu alters the cellular physiology of human health through infiltration of cellular membrane with various lesions, prone towards infection by Human papilloma virus (HPV) leading to high-risk cervical cancer (Oncology J. India, 4(2), 67-72, 2020).

The antibiotics resistance in microbe and their evolution is another area of our challenge. Besides, bio prospecting of industrial enzymes current research focuses on macro-molecular assembly of protein and carbohydrates interplay in host-pathogen interaction and regulation of cellular signaling in cancer metabolism during altered diseases condition. 



Projects

  1. “Isolation and characterization of Mycosporin like amino acid having UV-protective and anti-cancer potential”. (Department of Science & Technology, Govt. of Odisha, Sanctioned grants: Rs. 8,36,000/-; During 2014-2017, as Co-Investigator) 
  2. “Understanding the biology of bacterial vaginosis by sialidase detection and assessing its correlation with cervix cancer”. (Department of Science & Technology, Govt. of Odisha, Sanctioned grants: Rs. 8,16,000/-; During 2014-2017, as Co-Investigator)
  3. “Role of N-Acetylglucosamine (GlcNAc) in Microbial signaling during bacterial vaginosis”. (Science and Engineering Research Board (SERB), Department of Science & Technology, Government of India, Sanctioned grants: Rs. 46,22,000/-; Since 2017-2021, as Principal Investigator)
  1. Pattanayak B.S., Dehury, B., Priyadarshinee, M., Jha, S., Beuria, T.K., Soren, D., Mallick, B.C. (2021) Kanamycin-mediated conformational dynamics of Escherichia coli outer membrane protein TolC. Frontiers in Molecular Biosciences, 8: Article 636286, [doi:10.3389/fmolb.2021.636286].
  2. Nayak, B., Patnaik, P., Mohapatra, M., Soren, D., Patra, P., Besra, K., Giri, S.K. (2020) Bacterial Vaginosis and its association with Human Papilloma Virus and increased risk of Cervical Intraepithelial Lesions: An experience from Eastern India. Oncology Journal of India, 4(2), 67-72.
  3. Dutta T, Banerjee S, Soren D, Lahiri S, Sengupta S, Rasquinha JA, Ghosh AK. (2012) Regulation of enzymatic activity by deamidation and their subsequent repair by protein L-isoaspartyl methyl transferase. Appl Biochem Biotechnol. Vol. 168(8):2358-75.  
  4. Lahiri S, Basu A, Sengupta S, Banerjee S, Dutta T, Soren D, Chattopadhyay K, Ghosh AK. (2012) Purification and characterization of a trehalase-invertase enzyme with dual activity from Candida utilis. Arch Biochem Biophys. Vol. 15;522 (2):90-9
  5. Soren D, Jana M, Sengupta S, Ghosh AK.  (2010) Purification and characterization of a low molecular weight endo-xylanase from mushroom Termitomyces clypeatus. Appl Biochem BiotechnolVol. 162(2):373-89.

Book Chapter

  1. Swain A, Samanta L, Soren D. (2020) Thermostable Cyclodextrin Glycosyltransferase (CGTase): Recent Advances in Pharmaceutical Application of Cyclodextrins and Their Enzymatic Production. In “Bioresource Utilization and Management: Applications in Therapeutics, Biofuels, Agriculture, and Environmental Science” Edited by Thatoi, Das and Mohapatra. Apple Academic Press (ISBN:9781771889339), CRC Tylore & Francis Group. [Ahead of Publication Hard Copy on November 2020]
  1. Microbiology
  2. Biochemistry
  3. Molecular Biology
  4. Cell Biology
  5. Immunology and Cancer Biology