Rashmi Rekha Satapathy

She holds the position of Assistant Professor (Stage-III) at Department of Chemistry, Ravenshaw University. She has more than 10 years of teaching and research experiences in the extended field of organic chemistry. She has 24 publications in peer review journals to her credit. She completed her Ph.D in 2008 in organic synthesis. Her postdoctoral work at Northern Illinois University, USA was synthesis of carborane based organic and organometallic compounds.

Her current research interest is focused on designing and synthesis of various organic small molecules, study of photophysical properties of fluorescent molecules and development of fluorescent materials for sensing applications. Synthesis of carborane based biomolecules and dendritic macromolecules and study their anticancer activity in various cancer cell lines.

Selected Publications

  1. B. R. Swain, C. S. Mahanta, B. B. Jena, S. K. Beriha, B. Nayak, R. Satapathy, B. P. Dash, Preparation of dendritic carboranyl glycoconjugates as potential anticancer therapeutics, RSC Advances 2020, 10, 34764-34774.
  2. B. B. Jena, S.R.Jena, C. S. Mahanta, B. R. Swain, L. Samanta, B. P. Dash, R. Satapathy, Triazine-Cored Dendritic Molecules Containing Multiple Carborane Clusters, Appl. Organomet. Chem. 2020, 34, e5754.
  3. C. S. Mahanta, S. Aparna, S.K. Das, B. B. Jena, B. R. Swain, M. Patri, B. P. Dash, R. Satapathy, Star-Shaped Phenylene BODIPY: Synthesis, Properties and Biocompatibility Assessment using Zebrafish, Chemistry Select 2020, 5, 8429-8434.
  4. B. B. Jena, L. Satish, C. S. Mahanta, B. R. Swain, H. Sahoo, B. P. Dash, R. Satapathy, Interaction of carborane-appended trimer with bovine serum albumin: a spectroscopic investigation, Inorganica Chim. Acta, 2019, 491, 52-58.
  5. C. S. Mahanta, B. P. Dash, R. Satapathy, Cobaltabisdicarbollide Based Metallodendrimers with Cyclotriphosphazene Core, Journal of Organometallic Chemistry. 2018, 865, 183-188.

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About

Academics

ORGANIC SYNTHESIS GROUP

1. Dr. Bibhuti Bhusan Jena

Thesis Title: New Derivatives of Carboranes for Medicinal applications.

RSC poster prize winner at NPAFM-2017, Best oral lecture award at BDETP-2017, Dr. Bhagabat Nanda Memorial Award-2020 by Ravenshaw Chemistry Alumni Association.

E-mail ID: bibhu116@gmail.com

rasmi-bibhuti

2. Dr. Chandra Sekhara Mahanta

JRF in DST, CSIR sponsored

Project Thesis Title: Synthesis and Characterization of Carborane Containing Boron Dipyromethene 

PhD Awarded 2020

E-mail ID: – mahantachandrasekhara@gmail.com

rasmi-chandra

3. Biswa Ranjan Swain

JRF in DST sponsored Project

Synthesis and Evaluation of Carbohydrate Containing Bio-conjugates of Carborane for Cancer Therapy

PhD continuing

E-mail ID:  biswaranjan.swain1988@gmail.com

rasmi-biswa

4. Shubhalaxmi Mahanta

PhD Continuing 

Email:  shubhalaxmimahanta45@gmail.com

rasmi-shubhalaxmi

5. Abhisekh Pradhan

PhD Continuing 

Email: pradhanabhisekh1381996@gmail.com

rasmi-abhisekh

M. Phil.

Panchanan Behera (2020-Continuing) 

Monalisa Sahoo (2018-2019)

Dipti Ranjan Barik (2017-2018)

Narmada Behera (2016-2017)

Sushree Pragya Priyadarshinee Pany (2012-2013)

Prakash Kumar Sahoo (2011-2012)

Research

Carborane clusters act as a synthetic building blocks in the fields of materials science, catalysis and organometallic chemistry. Macromolecular and dendritic drug delivery agents  help in easy accumulation and retention in the tumour tissues due to their unique architectures. Therefore, incorporation of carboranes into dendritic macromolecules provides a valuable approach for the delivery of boron to the tumor tissues for successful treatment of cancer via BNCT. RSC Advances 2020, 10 (57), 34764–34774)

A series of carborane-appended glycoconjugates containing three and six glucose and galactose moieties have been synthesized via Cu(I)-catalyzed azide-alkyne [3+2] click cycloaddition reaction. The evaluation of cytotoxicities and IC50 values of newly synthesized carboranyl glycoconjugates was carried out using two cancerous cell lines (MCF-7 breast cancer cells and A431 skin cancer cells) and one normal cell line (HaCaT skin epidermal cell line). All carboranyl glycoconjugates showed higher cytotoxicities towards cancerous cell lines than the normal cell line. Carboranyl glycoconjugates containing three glucose and galactose moieties were found to be more cytotoxic than the glycoconjugates containing six glucose and galactose moieties. Thus, due to the higher cytotoxicities of dendritic carboranyl glycoconjugates towards cancer cells over healthy cells, they could potentially be useful for bimodal treatment of cancer such as chemotherapy agents and boron neutron capture therapy (BNCT) agents as well. Applied Organometallic Chemistry 2020, 5754-5761

A series of triazine-cored small dendritic molecules containing three to nine peripheral methyl-o-carborane clusters have been synthesized via Cu(I)-catalyzed Huisgen-type azide alkyne cycloaddition reactions (CuAAC). The thermal stability of the dendrimers were rised by increasing of methyl-o-carborane unit at the periphery of dendrimers. The IC50 value of nine cage dendrimer is 80.67 ng/mL which shows most toxic compared to other two carborane dendrimers in MCF-7 cell. Journal of Organometallic Chemistry. 2018, 865, 183-188)

Cyclotriphosphazene core based metallodendrimers containing six and twelve cobalt bis(dicarbollide) moieties on the periphery have been synthesized. The ring opening reaction  of the cyclic oxonium derivative of the cobalt bis(dicarbollide) anion,  [3,3’-Co(8-C4H8O2-1,2-C2B9H10)(1’,2’-C2B9H11)],  has been efficiently used for the synthesis of the dendrimers. The newly synthesized dendrimers have been characterized by 1H, 13C, 11B, 31P NMR and MALDI-TOF mass spectrometry, and the UV-Vis spectroscopy was used to determine the number of Cobaltabis(dicarbollide) units present in the dendrimers molecule. These dendrimers are extremely thermally robust, with 83% and 87% mass retention at 600 oC.

Publications

  1. B. R. Swain, C. S. Mahanta, B. B. Jena, S. K. Beriha, B. Nayak, R. Satapathy, B. P. Dash, Preparation of  dendritic carboranyl glycoconjugates as potential anticancer therapeutics, RSC Advance 2020, 10, 34764-34774. (Impact Factor: 3.07)
  2. C. S. Mahanta, S. Aparna, S.K. Das, B. B. Jena, B. R. Swain, M. Patri, B. P. Dash, R. Satapathy, Star-Shaped Phenylene BODIPY: Synthesis, Properties and Biocompatibility Assessment using Zebrafish, Chemistry Select 2020, 5, 8429-8434. (Impact Factor: 1.81)
  3. B. B. Jena, S.R.Jena, C. S. Mahanta, B. R. Swain, L. Samanta, B. P. Dash, R. Satapathy, Triazine-Cored Dendritic Molecules Containing Multiple Carborane Clusters, Appl. Organomet. Chem. 2020, DOI: 10.1002/aoc.575 4, 1-8 Appl. (Impact Factor: 3.14)
  4. B. B. Jena, L. Satish, C. S. Mahanta, B. R. Swain, H. Sahoo, B. P. Dash, R. Satapathy, Interaction of carborane-appended trimer with bovine serum albumin: a spectroscopic investigation, Inorganica Chim. Acta, 2019, 491, 52-58. (Impact Factor: 2.24)
  5. C. S. Mahanta, B. P. Dash, R. Satapathy, Cobaltabisdicarbollide Based Metallodendrimers with Cyclotriphosphazene Core, Journal of Organometallic Chemistry. 2018, 865, 183-188. (Impact Factor: 2.24)
  6. B. P. Dash, R. Satapathy, B. R. Swain, S. Mahanta, B. B. Jena, N. S. Hosmane, Cobalt bis(dicarbollide) anion and its derivatives, Journal of Organometallic Chemistry. 2017, 849-850, 170-194.(Impact Factor: 2.24)
  7. R. Satapathy, B. P. Dash, C. S. Mahanta, B. R. Swain, B. B. Jena, N. S. Hosmane, Glycoconjugates of Polyhedral Boron Clusters,  Journal of Organometallic Chemistry. 2015, 798, 13-23. (Impact Factor: 2.24)
  8. R. Satapathy, B.P. Dash, B. P. Bode, E. J. Byzawnski, S. Hosmane, S. Bux, N. S. Hosmane, New Classes of Carborane-Appended-5-thio-D-glucopyranose Derivatives,  Dalton Transactions, 2012, 41, 8982-8988. (Impact Factor: 4.17)
  9. B.P. Dash, R. Satapathy, B. P. Bode, C. T. Reidl, J. W. Sawicki, A. J. Mason, J. A. Maguire, N. S. Hosmane, “Click” Chemistry-Mediated Phenylene-Cored Carborane Dendrimers, Organometallics, 2012, 31, 2931-2935.(Impact Factor: 3.89)
  10. B.P. Dash, R. Satapathy, E. R. Gaillard, K. M. Norton, J. A. Maguire, N. Chug, N. S. Hosmane, Enhanced π-Conjugation and Emission via Icosahedral Carboranes: Synthetic and Spectroscopic Investigation, Inorganic Chemistry,2011, 50, 5485-5493.(Impact Factor: 4.82)
  11. R. Satapathy, B.P. Dash, C. Zheng, J. A.   Maguire, N. S. Hosmane, Carboranyl pyrroles: a Synthetic Investigation, Journal of Organic Chemistry, 2011, 76, 3562-3565. (Impact Factor: 4.78)
  12. B. P. Dash, R. Satapathy, J. A. Maguire, N. S. Hosmane, Polyhedral Boron Clusters in Materials Science, New Journal of  Chemistry, 2011, 35, 1955-1972. (Impact Factor: 3.28)
  13. L. Liang, A. A. Rapakousiou, R. Ruiz, D. Astruc, B.P. Dash, R. Satapathy, J. W. Sawicki, N. S. Hosmane, Click Assembly of Carborane-Appended Polymers and Stabilization of Gold and Palladium Nanoparticles, European Journal of Inorganic Chemistry 2011, 3043-3049. (Impact Factor: 2.68)
  14. B.P. Dash, R. Satapathy, E. R. Gaillard, J. A. Maguire, N. S. Hosmane, “Synthesis and Properties of Carborane-appended C3-symmetrical Extended π-systems, Journal of the American Chemical Society, 2010, 132, 6578-6587. Impact Factor: 14.89)
  15. B.P. Dash, R. Satapathy, J. A. Maguire, N. S. Hosmane, “Facile Synthetic Routes to Phenylene and Triazine Core Based Dendritic Cobaltabisdicarbollides” Organometallics, 2010, 29, 5230-5235.(Impact Factor: 3.89)
  16. R. Djeda, R. Ruiz, D. Astruc, R. Satapathy, B.P. Dash, N. S. Hosmane, Click Synthesis and Properties of Carborane-Appended Large Dendrimers, Inorganic Chemistry, 2010, 49, 10702-10709. (Impact Factor: 4.82)
  17. R. Satapathy, B.P. Dash, J. A. Maguire, N. S. Hosmane, New Developments in the Medicinal Chemistry of Carboranes, Coll. Czech. Chem. Commun., 2010, 75, 995-1022.(Impact Factor: 1.0) 
  18. R. Satapathy, B.P. Dash, J. A. Maguire, N. S. Hosmane, Advances in the metallacarborane chemistry of f-block elements, Dalton Transactions, 2010, 39, 6613-6625. (Impact Factor: 4.17)
  19. B. P. Dash, R. Satapathy, J. A. Maguire, N. S. Hosmane, Boron-Enriched Star-Shaped Molecule via Cycloaddition Reaction, Chemical Communications, 2009,3267-3269. (Impact Factor: 6.56) 
  20. B.P. Dash, R. Satapathy, J. A. Maguire, N. S. Hosmane, Synthesis of a New Class of Carborane-Containing Star-Shaped Molecules via Silicon Tetrachloride Promoted Cyclotrimerization Reactions, Organic Letters, 2008, 10, 2247-2250.(Impact Factor: 6.72)
  21. F. A. Khan, G. H. M. Rao, R. Satapathy, K. Parasuraman, Serendipitously Discovered Diazomethane-Mediated Novel Molecular Rearrangements of Norbornyl α-Ketohemiketals, Organic Letters, 2007, 9, 1581 -1584. (Impact Factor: 6.72)
  22. A New Reaction of Diazomethane with Norbornyl α-diketones, F. A. Khan, R. Satapathy, Ch. Sudheer, C. N. Rao. Tetrahedron Letters, 2005, 7193-7196.(Impact Factor: 2.4)
  23. F. A. Khan, R. Satapathy, J. Dash, G. Savitha. A Rapid and Stereoselective Route to the trans-Hydrindane Ring System, Journal of Organic Chemistry, 2004, 69, 5295-5301.(Impact Factor: 4.78)
  24. F. A. Khan, J. Dash, R. Satapathy, S. K. Upadhyay, Hydrotalcite catalysis in ionic liquid medium: a recyclable reaction system for heterogeneous Knoevenagel and nitroaldol condensation, Tetrahedron Letters,2004, 45, 3055-3058. (Impact Factor: 2.4)

 

Book Chapter

“Carborane clusters: versatile synthetic building blocks for dendritic, nanostructured and polymeric materials” B.P. Dash, R. Satapathy, J. A. Maguire, N. S. Hosmane,  Boron Science: New Technologies and Applications, CRC Press, Boca Raton, FL, USA, 2011, 675-699.