Bairagi C. Mallick

Dr. Mallick holds the post of Assistant Professor in the Department of Chemistry. He completed his Ph.D. in 2007 at IIT Bombay, India with Prof. Nand Kishore. Then, he moved to Seoul National University (SNU), Republic of Korea and worked with Prof. Sa-Ouk Kang as a KB-21 postdoctoral researcher. He joined the Department of Chemistry, Ravenshaw faculty in 2010. He has 11 years of teaching and 14 years of research experience. He has published in international peer review journals and written edited book chapters. He was awarded the prestigious Raman Postdoctoral Fellowship in 2016 by UGC, Govt. of India to conduct advance research in the University of Iowa, USA. He is a trained biophysical chemist with expertise in protein structure and functional nanoparticles research. His current research group is interested to unravel the complexity of proteins involved in antibiotics resistance, and the nano-bio interface chemistry of biogenic/engineered nanoparticles to facilitate their biomedical applications.

Selected Publications

  1. B. S. Pattanayak, M. Priyadarshinee, B. Dehury, S. Jha, T. K. Beuria, D. Soren and B. C. Mallick*, Kanamycin mediated conformational dynamics of Escherichia coli outer membrane protein TolC. Frontiers in Molecular Biosciences 2021, 8, 636286.
  2. N. Behera, M. Arakha, S. Soren, B. S. Pattanayak, M. Priyadashsinee, S. Jha and B. C. Mallick*, Oxidative stress generated at nickel oxide nanoparticle interface results in bacterial membrane damage leading to cell death. RSC Advances 2019, 9, 24888-24894.
  3. P. S. Nayak, M. Arakha, A. Kumar, S. Asthana and B. C. Mallick and S. Jha, Optimization of online silver nanoparticle biofabrication using Bacillus thuringiensis. RSC Advances 2016, 6, 8232-8242.
  4. M. Arakha, S. Pal, D. Samantarrai, T. K. Panigrahi, B. C. Mallick, K. Pramanik, B. Mallick and S. Jha, Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interfaces. Scientific Reports 2015, 5, 14813.
  5. M. Arakha, Md Saleem, B. C. Mallick and S. Jha, The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle. Scientific Reports 2015, 5, 9578.

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Academics

BIOPHYSICAL CHEMISTRY RESEARCH GROUP

1. Sanjukta Badhai

Ph.D. Program
Thesis Title: Effective delivery of phytosterol based drugs against colon cancer
E-mail: sanjukta.badhai@gmail.com
Contact No: + 91-9178665577
bairagi-sanjukta

2. Prangya P. Panda

Ph.D. Program
Thesis Title: Effects of Moringa Olefera extract phytosteroids on Mystus Gulio gonad development
E-mail: prangya.mana@gmail.com
Contact No: + 91-7682801178
bairagi-prangya

3. Mamali Priyadarshinee

Ph.D. Program
Thesis Title: Biochemical and biophysical interaction of PKM2 and HIF1a in breast cancer cell progression and metastasis.
E-mail: priyadarshinee1992@gmail.com ,  mpriyadarshinee.ls@ravenshawuniversity.ac.in 
Contact No: + 91-8249603863
bairagi-priyadarshinee

4. Nibedita Behera

Thesis Title: Biosynthesis of nanoparticles and their anticancer activity 
E-mail: nibeditamphil@ravenshawuniversity.ac.in
Contact No: +91-8917247453
bairagi-nibedita

5. Chitranjali Jena

Thesis title: Evaluation of anticancer activity of Triticum Aestinum (Wheat Grass)
E-mail ID: chitranjaliijena95@gmail.com
Contact No: +91-7978039495
bairagi-chitranjali

6. Sulata Kumari Sahu

Thesis Title: Effect of curcumin on TGF-β signaling mediated collagen expression and its role in regulation of β-amyloid formation in hypothyroid rat brain
Email ID : sulatasahu1994@gmail.com
Contact No: +91-9583031363/+91-7978292903
bairagi-sulata

LAB ALUMNI

7. Dr. Prakasini Satapathy

Thesis Title: Molecular characterisation of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis cases of Odisha
Email ID: prakasini.satapathy@gmail.com
Contact No.: + 91-8895143472
bairagi-prakasini

8. Dr. Biraja S. Pattanayak

Thesis Title: Biochemical and Biophysical Characterization of Drug Efflux Protein TolC in Escherichia coli.
E-mail ID: spbiraja@gmail.com, birajachemphd@ravenshawuniversity.ac.in
Contact No: +91-9439142596, +91-9853722917
bairagi-biraja

Research

The treatment of microbial infection and cancer has suffered greatly in the present century of pathogenic dominance. This prevailing situation has become a challenge to the active medical partitioners and to the scientific community. Thus, our long-term goal is to understand the mode/mechanism of antibiotics resistance both in bacteria/cancer  cells and identify naturally available drugs/antibiotics or develop biogenic/engineered nanoparticles to support/modify or replace the conventional used antibiotics that has led to cause resistance.

The emergence/existence of antibiotic resistance bacteria has evidenced to be associated with the overexpression of efflux pumps. These efflux pumps are either membrane or membrane associated proteins that have mediated antibiotic resistance through efflux mechanism. Thus, understanding the mechanism of antibiotics binding of these proteins and their efflux mechanism through the membrane is a real challenge, but in long run, it will help to improve the present condition of antibiotic resistance. Our approached is to purify membrane proteins in active state, and explore the antibiotics binding dynamics through biophysical techniques and substernal it through bioinformatic analysis.


The protective effects of naturally present phytosterols have been studied in various models and approaches. However, the exact mechanism of phytosterol action is still unknown. In our approach, we have identified different sources for extraction and purification of phytosterol of  interest and test their efficacy as an anticancer agent against breast cancer cells.

The rapid growth in nanotechnology has become the likelihood of engineered nanomaterials that coming into environmental and human contact. Nanoparticles interacting with cells membranes, DNA, proteins and organelles establish a series of nano-bio interfaces.  The study in our group aimed to evaluate the antimicrobial propensity of biogenic/synthesized NPs with significant anti-microbial activity. This will established potential use of NPs in biomedical and pharmaceutical sciences over the conventional antibiotics

Publications

  1. Biraja S. Pattanayak, MamaliPriyadarshinee, BudheswarDehury, Suman Jha, Tushar K. Beuria, Dhananjay Soren, Bairagi C. Mallick*.Kanamycin mediated conformational dynamics of Escherichia coli outer membrane protein TolC. Frontiers in Molecular Biosciences, 2021, 8, 636286). doi.org/10.3389/fmolb.2021.636286
  2. Sanjukta Badhai, Durga Barik and Bairagi C. Mallick*. Anticancer efficacy of β-sitosterol loaded hydroxyapatite-alginate on colon cancer cell in-vivo. Research J. Pharm. and Tech. 2020, 13(3), 1147-1151. doi: 10.5958/0974-360x.2020.00211.5 
  3. S. Mishra, M. Priyadarshinee, A. K. Debnath, K. P. Muthe, B. C. Mallick, N. Das, P. Parhi. Rapid microwave assisted hydrothermal synthesis cerium vanadate nanoparticle and its photocatalytic and antibacterial studies. Journal of Physics and Chemistry of Solids 2020, 137, 10211-10219. doi.org/10.1016/j.jpcs.2019.109211
  4. Nibedita Behera, Manoranjan Arakha, Siba Soren, Biraja S. Pattanayak, Mamali Priyadashsinee, Suman Jha and Bairagi C. Mallick*. Oxidative stress generated at nickel oxide nanoparticle interface results in bacterial membrane dmge leading to cell death. RSC Advances 2019, 9, 24888-24894. doi.org/10.1039/C9RA02082A
  5. Parth Sarthi Nayak, Manoranjan Arakhaa, Ajeet Kumar, Shreyasi Asthana and Bairagi C. Mallick and Suman Jha. Optimization of online silver nanoparticle biofabrication using Bacillus thuringiensis. RSC Advances 2016, 6, 8232-8242. doi.org/10.1039/C5RA21281B
  6. ManoranjanArakhaa, Sweta Pala, Devyani Samantarraia, Tapan K. Panigrahid, Bairagi C. Mallick, Krishna Pramanikb, Bibekanand Mallick and Suman Jhaa. Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interfaces. Scientific Reports 2015,|5:14813 | doi: 10.1038/srep14813.
  7. Bairagi C. Mallick*.Effects of Sarcosine on the Stability of Cytochrome C., IJSR, 2014, 4(9), 2277-8179.
  8. Manoranjan Arakha, Mohammed Saleem, Bairagi C. Mallick and Suman Jha, The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle, SCIENTIFIC REPORTS | 2015, 5: 9578 | doi: 10.1038/srep09578.
  9. Bairagi C. Mallick*, Sa-Ouk Kang and Suman Jha. Ca2+-binding induces conformational stability of CAF-1 from Dictyosteliumdiscoideum. J. Chem. Sci. 2014,126 (3), 751–761. 
  10. Bairagi C. Mallick and Nand Kishore, Partial molar volumes of some alpha-amino acids in aqueous magnesium sulphate solutions at 298.15 K, J. Solution Chem. 2006,35,1441-1451

Book Chapters

  1. ManoranjanArakha, Bairagi C. Mallick and Suman Jha. Magnetic Nanoparticle Interface with an Antimicrobial Propensity, May, 2019, Springer Nature Switzerland AG 2019, K.A. Abd-Elsalam et al. (eds.), Magnetic Nanostructure, Nanotechnology in the Life Sciences. (ISBN: 978-3-030-16439-3)
  2. Arakha, M., Rath, S. K., Pradhan, A. K., Mallick, B. C., Jha, S., Protein-nanoparticle interaction and its potential biological implications. Bioprospecting of Enzymes in Industry, Healthcare and Sustainable Environment. Springer, PP-155-173. (ISBN: 978-981-33-4195-1)