Organic Synthesis

Sabita Nayak

Room No.
Chemistry Department

+91-9692155759

sabitanayak18[at]gmail[dot]com

Dr. Sabita Nayak currently an Associate Professor at Department of Chemistry. She has more than 11 years of teaching and research experience in the extended field of organic synthesis and medicinal chemistry research. She has 36 publications in peer reviewed journals to her credit. She completed Ph.D. on 2008 from NCL, Pune under the supervision of Dr. Mukund Gurjar.. The thesis work was based on “Synthetic studies toward the total synthesis of Eunicin, Palau’amide and Asimitrin”. After completion her Ph.D., she was worked as a Research Associate in Chembiotek, Pharma- Ltd, Pune. Her postdoctoral work at University of Southwestern Medical Research Center, Dallas, Texas, USA consisted of medicinal chemistry research. She has special interest in natural product synthesis, hybrid natural product synthesis, medicinal chemistry, Carbohydrate Chemistry and 1,3 dipolar cycloaddition reaction.

Selected Publications

  1. D. R. Mishra, S. Nayak, B. P. Raiguru, S. Mohapatra, M. B. Podh, C. R. Sahoo, R. N. Padhy, Synthesis of (4S)-4-C-spiro-glycosyl-chromeno-[3,4-d][1,2,3]triazoles: Biological evaluation and molecular docking investigation, Journal of Heterocyclic Chemistry, 2021 , 58 ,111–126
  2. B. P. Raiguru, S. Nayak, D. R. Mishra, T. Das, S. Mohapatra, N. P. Mishra, Synthetic Applications of Cyclopropene and Cyclopropenone: Recent Progress and Developments, Asian journal of organic chemistry, 2020, 9,1088-1132
  3. S. Nayak, P. Panda, B. P. Raiguru, S. Mohapatra and C. S. Purohit Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes, Org. Biomol. Chem., 2019,17, 74-82
  4. P. Panda, S. Nayak, S. K. Sahoo, S. Mohapatra, D. Nayak, R.Pradhanb  and  C.N. Kundu, Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction and in vitro anticancer studies, RSC Adv., 2018,8, 16802-16814
  5. P. Pattanaik, S. Nayak, D.R. Mishra, P. Panda, B. P. Raiguru, N. P. Mishra, S. Mohapatra, N.A. Mallampudi, C. S.Purohit. One pot, three component 1,3 dipolar cycloaddition: Regio and diastereoselective synthesis of spiropyrrolidinyl indenoquinoxaline derivatives, Tetrahedron Letters, 2018, 59, 2688-2694
  • Group
  • Research
  • Publications
  • Teaching

Deepak Ranjan Mishra

Research Scholar

Jasmine Panda

Research Scholar

WhatsApp Image 2022-01-06 at 10.04.51 PM

Rachita Raulo

Research Scholar

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Bhabani Shankar Panda

Research Scholar

Arup Kumar Dash

Research Scholar

Group Alumni

Subhendu Chakroborty

Ph.D. Awarded: 2015

Sambita Kumar Mishra

Ph.D. Awarded: 2016

Sujitlal Bhakta

Ph.D. Awarded: 2016

Priyabrata Patanaik

Ph.D. Awarded: 2019

Pravati Panda

Ph.D. Awarded: 2019

Nilofar Baral

Ph.D. Awarded: 2020

Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes

A novel green synthetic methodology has been developed to obtain enantiopure (2S)-2-C-spiro-glycosyl-3-nitrochromenes following the oxa-Michael–aldol condensation reaction of sugar derived 3-C-vinyl nitro olefins with substituted salicylaldehydes using Et3N as a base under neat conditions at rt–40 °C. The stereochemistry of the product is confirmed by a single crystal X-ray study. Several advantages are associated with this protocol such as cost effectiveness, easy accessibility, short reaction time, high yields, wide substrate scope and high enantiopurity.

Microwaveassisted Onepot, Threecomponent Regiospecific and Sterospecific Synthesis of Spiro Indanone Pyrrolidine/Piperidine Fused Nitrochromene Derivatives Through 1,3Dipolar Cycloaddition Reactions

The synthesis of a new series of spirocyclic molecules has been expediently accomplished via a onepot, three component 1,3dipolar cycloaddition reaction. 2Phenylnitrochromene dipolarophiles were reacted with azomethine ylides, generated in situ by the condensation of dicarbonyl compound indane1,3dione and secondary amino acid (Lproline/pipecolic acid), to produce the corresponding cycloadducts in good yields (85–90%) under classical as well as under microwave irradiation. The cycloaddition reaction was found to be highly regiospecific and diasterospecific.

Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction and in vitro anticancer studies

A diastereoselective oxa-hetero-Diels–Alder reaction for the synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives and studied their in vitro anticancer activities.

Completed Research Project

  1. DST Project: 2012-2015. Project Title: Design and Synthesis of Novel αβ and γ amido boronic acids as therapeutics.
  2. UGC Project: 2013-2016. Project Title: Design and synthesis of novel hybrid natural products as potential antimalarial drug.
  3. CSIR Project: 2015-2018. Project Title: Design and Synthesis of Novel Hybrid natural product as potential BCRP Inhibitors.

Continuing Research Project

  1. DST ODISHA Project: 2019-2022. Project Title: Synthesis of novel Chromene based spirocyclic molecules as anticancer agent.
  2. DRDO, LSRB Project: 2021-2024. Project Title: Design, synthesis and evaluation of sugar conjugated pyridine oximes as reactivators of organophosphorous nerve agent inhibited acetylcholinesterase.
  3. DRDO Project: 2017-2021. Project Title: Design and synthesis of flavone-stilbene based hybrid natural products as potent antimalarial agent.
  4. CSIR Project: 2019-2022. Project Title: Synthesis of novel spiroindanone fused (3,2-c) chromene derivatives as BCRP/ABCG2 Inhibitors.
  1. Acharya, B. N.; Ghorpade, R. R.; Singh, K. P.; Kumar, D.; Nayak. S. Monatshefte für Chemie – Chemical Monthly 2021, 152 (3), 357-366 doi.org/10.1007/s00706-021-02752-4.
  2. Ghorpade, R. R.; Kumar, D.; Nayak. S. Acharya, B. N.; Monatshefte für Chemie-Chemical Monthly , 2019, 150, 1335
  3. Mishra, N. P.; Sahoo, D. K, Mohapatra, S.; Nayak, S.; Nayak, D. Journal of Microencapsulation2021, Communicated. 
  4. Mishra, N. P.; Mohapatra, S.; Sahoo, C.R.; Raiguru, B. P.; Nayak, S.; Jena, S.; Padhy, R.N.; Journal of molecular structure2021, communicated. 
  5. Mishra, M.; Mishra, N. P.; Raiguru, B. P.; Das, T.; Mohapatra, S.; Nayak, S.; Mishra, D. R.; Panda, J.; Sahoo, D.K, ChemistrySelect2021, Accepted. 
  6. Das, T.; Mohapatra, S.; Mishra, N. P.; Nayak, S.; Raiguru, B. P. ChemistrySelect2021, Accepted. 
  7. Mishra, D. R.; Nayak, S.; Raiguru, B. P.; Mohapatra, S.; Podh, M. B. Sahoo, C. R.; Padhy R. N. Journal of Heterocyclic Chemistry, 2021, 58, 111-126. 
  8. Mishra, N. P.; Satish. L.; Mohapatra, S.; Panda, P.; Nayak, SResearch on chemical intermediates2021, 47, 1181–1195.
  9. Raiguru, B. P.; Nayak, S.; Mishra, D. R.; Das, T.; Mohapatra, S.; Mishra, N. P. Asian Journal of Organic Chemistry, 20209, 1088-1132.
  10. Baral, N.; Mishra, D. R.;  Mishra, N. P; Mohapatra, S.; Raiguru, B. P.;  Panda, P.; NayakS. Nayak, M.; Sudir Kumar, P. Journal of heterocyclic chemistry2019, doi:10.1002/jhet.3773. 
  11. Mishra, M..; Mohapatra, S.; Mishra, N. P.; Jena, B. K.; Panda, P.; Nayak, STetrahedron Letters2019,60(33), doi:10.1016/j.tetlet.2019.07.016. 
  12. Nayak, S.; Pattanaik, P.; Mohapatra, S.; Mishra, D. R.; Panda, P.; Raiguru, B. P.; Biswal, H. S. Synthetic Communications, 20191–13. doi:10.1080/00397911.2019.1606919.
  13. Nayak, S.; Panda, P.; Mohapatra, S.; Raiguru, B.;  Baral, N.  Journal of Heterocyclic Chemistry. 2019. doi:10.1002/jhet.3534. 
  14. NayakS. ; Panda, P.;  Raiguru, B. P.; Mohapatra, S.; Purohit, C. S. Organic & Biomolecular Chemistry, 2019, 17, 74-82 (DOI: 10.1039/c8ob02278j)
  15. Baral,N.; Mohapatra,S.; Mishra, N.P; Raiguru, B.P.;  Panda, P.; NayakS. Journal of heterocyclic chemistry2019, 56(2), 552-565. doi.org/10.1002/jhet.3430
  16. Baral,N.; Mohapatra,S.; Pal, S.N.; NayakS. 5-(2-Chlorophenyl)-3-(2 H -chromen-3-yl)-1,2,4-oxadiazole, IUCrData 3, x180129. 2018,  . DOI: 10.1107/S2414314618001293.
  17. Mishra, N.P.; Mohapatra,S.; Panda, P.; NayakS., Current Organic Chemistry, 2018, 22, 1959 – 1985. 
  18. Panda, P.; NayakS.; Sahoo, S.; Mohapatra, S. RSC Advances, 20188, 16802-16814.
  19. Pattnaik, P.; NayakS.; Mishra, D. R.; Panda, P.; Raiguru, B. P.; Mishra, N. P.; Mohapatra, S.; Mallmpudi, N. A.; Purohit, C. S. Tetrahedron Letters201859 2688-2694.
  20. Panda,  P.; NayakS.; Bhakta, S.; Mohapatra, S.; Murthy, T. R Journal of Chemical Sciences. 2018130:127
  21. Mohapatra, S.; Baral, N.; Mishra, N.P.; Nayak, SOpen Chemistry Journal, 2018, 5, 18-31.
  22. Baral, N.; NayakS, Pal, S.; Mohapatra, S., Data Report, 2018, 3, 180129.
  23. NayakS.; Panda,  P.; Bhakta, S.; Mohapatra, S, Mishra, S. K. RSC Advances2016, 6, 96154.
  24. Nayak, S.; Mishra, S.K.; Bhakta, S.; Panda, P.; Baral, N.; Mohapatra, S.; Purohit, C.S.; Seta, P., Lett. in Organic Chemistry, 2016, 13, 11-21 .
  25. Nayak, S.; Chakroborty, S.; Bhakta, S.; Panda, P.; Mohapatra, S. Res. Chem. Int. 201642, 2731–2747.
  26. Nayak, S.; Chakroborty, S.; Bhakta, S.; Panda, P.; Mohapatra, S.; Kumar, S.; Jena, P.K.; Purohit, C. Letter in Organic Chemistry  2015, 12,  1-7.
  27. Mohapatra, S.; Bhakta, S.;Chakroborty, S.; Tripathy, M.; Nayak, S. Res. Chem. Int. 2015417799-7813.
  28. Mohapatra, S.; Bhakta, S.; Baral, N.; Nayak, SRes. Chem. Int. 2015, 41, 4545-4553.
  29. Mohapatara, S.; Bhanja, C.; Jena. S.; chakraborty, S.; Nayak, SSyn. Comm.2013.43, 1-15.
  30. Mohapatra, S.; Nayak, S.; Mishra, S.K.; Pattanik,P. Lett. in Organic Chemistry, 201310, 65-69.
  31. Mohapatara, S.; Bhanja, C.; Chakraborty, S.; Nayak, SRes. Chem. Int. 201339, 1459-1462.
  32. Bhanja, C.; Jena. S.; Nayak, S.; Mohapatra, S. BJournal of Organic Chemistry, 20128,1668-1694.
  33. Das, B.C.; Tang, X.Y; Sanyal, S; Mohapatra, S; Rogler, P; Nayak, S; Evans, T.  Tetrahedron Letter201152, 2433-2435. 
  34. Mohapatra D.K.; Naidu P.R.; Reddy, D.S.; Nayak, S; Mohapatra, S.; . E.Journal of Organic Chemistry  2010, 6263-6268.
  35. Das, B.C.; Mohapatra S.; Campbell P.D.; Nayak, S.; Mahalingam, S.M,; Evans T. 2010, 51(19), 2567-2570.
  36. Mohapatra D. K.; Nayak S.; Mohapatra S.; Chorghade M.S. and Gurjar M. K. Tetrahedron Lett., 200748, 5197- 5200. 
  37. Mohapatra D. K., Nayak, S. Stereoselective synthesis of C-28 to C-33 Fragment of Palau’amide. Tetrahedron Letter,  200849, 786-789. 
  38. Gurjar, M. K.;   Nayak, S.; Ramana C.V. Tetrahedron Letter, 200546, 1881-1884.

Teaching :

  1. Pericyclic reaction
  2. Photochemistry
  3. colour and dyes
  4. elimination reaction and radical reactions
  5. bioorganic chemistry
  6. spectroscopy
  7. carbonyl compounds