Sabita Nayak

Dr. Sabita Nayak currently an Assistant Professor at Department of Chemistry. She has more than 11 years of teaching and research experience in the extended field of organic synthesis and medicinal chemistry research. She has 36 publications in peer reviewed journals to her credit. She completed Ph.D. on 2008 from NCL, Pune under the supervision of Dr. Mukund Gurjar.. The thesis work was based on “Synthetic studies toward the total synthesis of Eunicin, Palau’amide and Asimitrin”. After completion her Ph.D., she was worked as a Research Associate in Chembiotek, Pharma- Ltd, Pune. Her postdoctoral work at University of Southwestern Medical Research Center, Dallas, Texas, USA consisted of medicinal chemistry research. She has special interest in natural product synthesis, hybrid natural product synthesis, medicinal chemistry, Carbohydrate Chemistry and 1,3 dipolar cycloaddition reaction.

Selected Publications

  1. D. R. Mishra, S. Nayak, B. P. Raiguru, S. Mohapatra, M. B. Podh, C. R. Sahoo, R. N. Padhy, Synthesis of (4S)-4-C-spiro-glycosyl-chromeno-[3,4-d][1,2,3]triazoles: Biological evaluation and molecular docking investigation, Journal of Heterocyclic Chemistry, 2021 , 58 ,111–126
  2. B. P. Raiguru, S. Nayak, D. R. Mishra, T. Das, S. Mohapatra, N. P. Mishra, Synthetic Applications of Cyclopropene and Cyclopropenone: Recent Progress and Developments, Asian journal of organic chemistry, 2020, 9,1088-1132
  3. S. Nayak, P. Panda, B. P. Raiguru, S. Mohapatra and C. S. Purohit Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes, Org. Biomol. Chem., 2019,17, 74-82
  4. P. Panda, S. Nayak, S. K. Sahoo, S. Mohapatra, D. Nayak, R.Pradhanb  and  C.N. Kundu, Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction and in vitro anticancer studies, RSC Adv., 2018,8, 16802-16814
  5. P. Pattanaik, S. Nayak, D.R. Mishra, P. Panda, B. P. Raiguru, N. P. Mishra, S. Mohapatra, N.A. Mallampudi, C. S.Purohit. One pot, three component 1,3 dipolar cycloaddition: Regio and diastereoselective synthesis of spiropyrrolidinyl indenoquinoxaline derivatives, Tetrahedron Letters, 2018, 59, 2688-2694.






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Dr. Sabita Nayak’s Group

1. Deepak Ranjan Mishra

Education: M.Sc Chemistry ( Ravenshaw University,2017)

B.Sc. Chemistry (Ravenshaw University, Cuttack, 2015)

Role: NET SRF fellow

Research Project: Synthesis of 2-C-spiro-Glycosyl-Chromene fused heterocycles following 1,3-dipolar cycloaddition reaction.

Email-id :


2. Jasmine Panda

Education: M.Sc Chemistry ( Berhampur University,2020)

B.Sc. Chemistry (Berhampur University, 2018)

Role: DST Odisha Project fellow          

Research Project: Asymmetric Aza- Michael addition reaction of Nitrogen nucleophiles to 3-nitro-2-phenyl-2H-chromene using organocatalyst and its biological studies.



3. Rachita Raulo

Education: M.Sc Chemistry ( CET, BPUT, 2020)

B.Sc. Chemistry (Utkal University, 2018)

Role: Ph.D. Scholar          

Research Project: Synthesis of chromene based biologically active molecules.



4. Bhabani Shankar Panda

Education: M.Sc Chemistry (Berhampur University, 2018)

B.Sc. Chemistry (Utkal University, 2016)

Role: CSIR SRF Fellow          

Research Project: Synthesis of heterocyclic using Azamichael addition reaction. 



5. Arup Kumar Dash

Education: M.Sc Chemistry ( North Orissa University, 2020)

B.Sc. Chemistry (Utkal University, Cuttack, 2018)

Role: M.Phil. Scholar

Research Project: Synthesis of chromene functionalized molecules.




1. Subhendu Chakroborty

Ph.D. Awarded: 2015

Current position: Assistant Professor in Auro University,Gujurat


2. Sambita Kumar Mishra

Ph.D. Awarded: 2016

Current Position: Lecturer in Chemistry, D.A.V. Public school, Cuttack

Email Id:


3. Sujitlal Bhakta

 Ph.D. Awarded: 2016

Current Position: Research Associate (Biochemistry), Anthropological Survey of India, Ministry of Culture, Govt. of India


4. Priyabrata Patanaik

Ph.D. Awarded: 2019

Current Position: Assistant Professor in Govt. Auto college, Phulbani.


5. Pravati Panda

Ph.D. Awarded: 2019

Current position: Guest Faculty in Ramadevi University, Bhubaneswar


6. Nilofar Baral

Ph.D. Awarded: 2020

Current Position: Lecturer in kamakhyanagar Auto College, Dhenkanal

Email. Id:



  1. Monalisha Nayak-2011
  2. Tapan Kumar Behera-2012
  3. Soumyaranjan Pati- 2013
  4. Pravanjan Behera- 2015
  5. Satyabrata Subudhi-2016
  6. Kedarnath Sahani-2018
  7. Sidharth Sankar Panda-2019


Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes

A novel green synthetic methodology has been developed to obtain enantiopure (2S)-2-C-spiro-glycosyl-3-nitrochromenes following the oxa-Michael–aldol condensation reaction of sugar derived 3-C-vinyl nitro olefins with substituted salicylaldehydes using Et3N as a base under neat conditions at rt–40 °C. The stereochemistry of the product is confirmed by a single crystal X-ray study. Several advantages are associated with this protocol such as cost effectiveness, easy accessibility, short reaction time, high yields, wide substrate scope and high enantiopurity.

Microwaveassisted Onepot, Threecomponent Regiospecific and Sterospecific Synthesis of Spiro Indanone Pyrrolidine/Piperidine Fused Nitrochromene Derivatives Through 1,3Dipolar Cycloaddition Reactions

The synthesis of a new series of spirocyclic molecules has been expediently accomplished via a onepot, three component 1,3dipolar cycloaddition reaction. 2Phenylnitrochromene dipolarophiles were reacted with azomethine ylides, generated in situ by the condensation of dicarbonyl compound indane1,3dione and secondary amino acid (Lproline/pipecolic acid), to produce the corresponding cycloadducts in good yields (85–90%) under classical as well as under microwave irradiation. The cycloaddition reaction was found to be highly regiospecific and diasterospecific.

Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction and in vitro anticancer studies

A diastereoselective oxa-hetero-Diels–Alder reaction for the synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives and studied their in vitro anticancer activities.

Completed Research Project

  1. DST Project: 2012-2015. Project Title: Design and Synthesis of Novel αβ and γ amido boronic acids as therapeutics.
  2. UGC Project: 2013-2016. Project Title: Design and synthesis of novel hybrid natural products as potential antimalarial drug.
  3. CSIR Project: 2015-2018. Project Title: Design and Synthesis of Novel Hybrid natural product as potential BCRP Inhibitors.

Continuing Research Project

  1. DST ODISHA Project: 2019-2022. Project Title: Synthesis of novel Chromene based spirocyclic molecules as anticancer agent.
  2. DRDO, LSRB Project: 2021-2024. Project Title: Design, synthesis and evaluation of sugar conjugated pyridine oximes as reactivators of organophosphorous nerve agent inhibited acetylcholinesterase.
  3. DRDO Project: 2017-2021. Project Title: Design and synthesis of flavone-stilbene based hybrid natural products as potent antimalarial agent.
  4. CSIR Project: 2019-2022. Project Title: Synthesis of novel spiroindanone fused (3,2-c) chromene derivatives as BCRP/ABCG2 Inhibitors.


  1. Acharya, B. N.; Ghorpade, R. R.; Singh, K. P.; Kumar, D.; Nayak. S. Monatshefte für Chemie – Chemical Monthly 2021, 152 (3), 357-366
  2. Ghorpade, R. R.; Kumar, D.; Nayak. S. Acharya, B. N.; Monatshefte für Chemie-Chemical Monthly , 2019, 150, 1335
  3. Mishra, N. P.; Sahoo, D. K, Mohapatra, S.; Nayak, S.; Nayak, D. Journal of Microencapsulation, 2021, Communicated. 
  4. Mishra, N. P.; Mohapatra, S.; Sahoo, C.R.; Raiguru, B. P.; Nayak, S.; Jena, S.; Padhy, R.N.; Journal of molecular structure, 2021, communicated. 
  5. Mishra, M.; Mishra, N. P.; Raiguru, B. P.; Das, T.; Mohapatra, S.; Nayak, S.; Mishra, D. R.; Panda, J.; Sahoo, D.K, ChemistrySelect, 2021, Accepted. 
  6. Das, T.; Mohapatra, S.; Mishra, N. P.; Nayak, S.; Raiguru, B. P. ChemistrySelect, 2021, Accepted. 
  7. Mishra, D. R.; Nayak, S.; Raiguru, B. P.; Mohapatra, S.; Podh, M. B. Sahoo, C. R.; Padhy R. N. Journal of Heterocyclic Chemistry, 2021, 58, 111-126. 
  8. Mishra, N. P.; Satish. L.; Mohapatra, S.; Panda, P.; Nayak, S. Research on chemical intermediates, 2021, 47, 1181–1195.
  9. Raiguru, B. P.; Nayak, S.; Mishra, D. R.; Das, T.; Mohapatra, S.; Mishra, N. P. Asian Journal of Organic Chemistry, 2020, 9, 1088-1132.
  10. Baral, N.; Mishra, D. R.;  Mishra, N. P; Mohapatra, S.; Raiguru, B. P.;  Panda, P.; Nayak, S. Nayak, M.; Sudir Kumar, P. Journal of heterocyclic chemistry, 2019, doi:10.1002/jhet.3773. 
  11. Mishra, M..; Mohapatra, S.; Mishra, N. P.; Jena, B. K.; Panda, P.; Nayak, S. Tetrahedron Letters. 2019,60(33), doi:10.1016/j.tetlet.2019.07.016. 
  12. Nayak, S.; Pattanaik, P.; Mohapatra, S.; Mishra, D. R.; Panda, P.; Raiguru, B. P.; Biswal, H. S. Synthetic Communications, 2019. 1–13. doi:10.1080/00397911.2019.1606919.
  13. Nayak, S.; Panda, P.; Mohapatra, S.; Raiguru, B.;  Baral, N.  Journal of Heterocyclic Chemistry. 2019. doi:10.1002/jhet.3534. 
  14. Nayak, S. ; Panda, P.;  Raiguru, B. P.; Mohapatra, S.; Purohit, C. S. Organic & Biomolecular Chemistry, 2019, 17, 74-82 (DOI: 10.1039/c8ob02278j)
  15. Baral,N.; Mohapatra,S.; Mishra, N.P; Raiguru, B.P.;  Panda, P.; Nayak, S. Journal of heterocyclic chemistry, 2019, 56(2), 552-565.
  16. Baral,N.; Mohapatra,S.; Pal, S.N.; Nayak, S. 5-(2-Chlorophenyl)-3-(2 H -chromen-3-yl)-1,2,4-oxadiazole, IUCrData 3, x180129. 2018,  . DOI: 10.1107/S2414314618001293.
  17. Mishra, N.P.; Mohapatra,S.; Panda, P.; Nayak, S., Current Organic Chemistry, 2018, 22, 1959 – 1985. 
  18. Panda, P.; Nayak, S.; Sahoo, S.; Mohapatra, S. RSC Advances, 2018, 8, 16802-16814.
  19. Pattnaik, P.; Nayak, S.; Mishra, D. R.; Panda, P.; Raiguru, B. P.; Mishra, N. P.; Mohapatra, S.; Mallmpudi, N. A.; Purohit, C. S. Tetrahedron Letters, 2018, 59,  2688-2694.
  20. Panda,  P.; Nayak, S.; Bhakta, S.; Mohapatra, S.; Murthy, T. R Journal of Chemical Sciences. 2018, 130:127
  21. Mohapatra, S.; Baral, N.; Mishra, N.P.; Nayak, S. Open Chemistry Journal, 2018, 5, 18-31.
  22. Baral, N.; Nayak, S, Pal, S.; Mohapatra, S., Data Report, 2018, 3, 180129.
  23. Nayak, S.; Panda,  P.; Bhakta, S.; Mohapatra, S, Mishra, S. K. RSC Advances, 2016, 6, 96154.
  24. Nayak, S.; Mishra, S.K.; Bhakta, S.; Panda, P.; Baral, N.; Mohapatra, S.; Purohit, C.S.; Seta, P., Lett. in Organic Chemistry, 2016, 13, 11-21 .
  25. Nayak, S.; Chakroborty, S.; Bhakta, S.; Panda, P.; Mohapatra, S. Res. Chem. Int. 2016, 42, 2731–2747.
  26. Nayak, S.; Chakroborty, S.; Bhakta, S.; Panda, P.; Mohapatra, S.; Kumar, S.; Jena, P.K.; Purohit, C. Letter in Organic Chemistry  2015, 12,  1-7.
  27. Mohapatra, S.; Bhakta, S.;Chakroborty, S.; Tripathy, M.; Nayak, S. Res. Chem. Int. 2015, 41, 7799-7813.
  28. Mohapatra, S.; Bhakta, S.; Baral, N.; Nayak, S. Res. Chem. Int. 2015, 41, 4545-4553.
  29. Mohapatara, S.; Bhanja, C.; Jena. S.; chakraborty, S.; Nayak, S. Syn. Comm.2013., 43, 1-15.
  30. Mohapatra, S.; Nayak, S.; Mishra, S.K.; Pattanik,P. Lett. in Organic Chemistry, 2013, 10, 65-69.
  31. Mohapatara, S.; Bhanja, C.; Chakraborty, S.; Nayak, S. Res. Chem. Int. 2013, 39, 1459-1462.
  32. Bhanja, C.; Jena. S.; Nayak, S.; Mohapatra, S. B. Journal of Organic Chemistry, 2012, 8,1668-1694.
  33. Das, B.C.; Tang, X.Y; Sanyal, S; Mohapatra, S; Rogler, P; Nayak, S; Evans, T.  Tetrahedron Letter, 2011, 52, 2433-2435. 
  34. Mohapatra D.K.; Naidu P.R.; Reddy, D.S.; Nayak, S; Mohapatra, S.; . E.Journal of Organic Chemistry  2010, 6263-6268.
  35. Das, B.C.; Mohapatra S.; Campbell P.D.; Nayak, S.; Mahalingam, S.M,; Evans T. 2010, 51(19), 2567-2570.
  36. Mohapatra D. K.; Nayak S.; Mohapatra S.; Chorghade M.S. and Gurjar M. K. Tetrahedron Lett., 2007, 48, 5197- 5200. 
  37. Mohapatra D. K., Nayak, S. Stereoselective synthesis of C-28 to C-33 Fragment of Palau’amide. Tetrahedron Letter,  2008, 49, 786-789. 
  38. Gurjar, M. K.;   Nayak, S.; Ramana C.V. Tetrahedron Letter, 2005, 46, 1881-1884.


  1. Pericyclic reaction
  2. Photochemistry
  3. colour and dyes
  4. elimination reaction and radical reactions
  5. bioorganic chemistry
  6. spectroscopy
  7. carbonyl compounds.